Aromatase plays a key role in breast carcinogenesis; therefore, the growth of breast cancer is . Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. Design and methods. In addition, ellagic acid can also act as a sunscreen, which scavenges oxygen free radicals (Xu et al., 2012). First, ellagic acid kills cancer cells by promoting cell death (apoptosis). These observations provide mechanistic insights into the new molecular events behind the chemoprevention action of ellagic acid in and treatment of breast cancer. Three time pointsearly (6 wk), intermediate (18 wk), and late (24 wk)were chosen, and the . 120. In order to determine whether berries and ellagic acid affect estrogen metabolism, we examined the regulation of gene expression of key enzymes involved in estrogen metabolism and signaling, in the mammary tissue during the course of mammary tumorigenesis. PubMed journal article: Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Beefsteak Fungus. Raspberries are one of the few sources of ellagitannins that your body can transform into useful levels of ellagic acid. Ellagic acid is a promoter of glutathione transferase (GSTM) as well as NQO1 (quinone reductase) (3). . By using our site, you agree to our collection of information through the use of . Background Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. Ellagic Acid - Read online for free. Edderkaoui M, Odinokova I . Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. Plant foods contain thousands of natural chemicals. Endometrium . In this study, we investigated efficacy of dietary berries and ellagic acid to reduce estrogen-mediated mammary tumorigenesis. Cells co . Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) ++ transcript in estrogen receptor-positive MCF-7 breast cancer cells Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. In laboratory studies, ellagic acid showed antiviral, antibacterial and . Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. 2267 Elevated levels of estrogen are associated with higher risk for breast cancer. 20, pp. Thread starter bossman523; Start date May 8, 2013; bossman523 Banned. . Endometrium . . Its healing quality is due to the phytochemicals present in the plant. Ellagic acid was selected based on >95% inhibition of 8-oxodeoxyguosine (8-oxodG) and other unidentified oxidative DNA adducts induced by 4-hydroxy-17-estradiol and CuCl2 in vitro. The administration of Ellagic acid, Kaempferol, and Quercetin as combined drug via the novel drug delivery systems will be a valuable therapeutic choice for the . In addition, a previous report claimed that ellagic acid is a natural selective estrogen receptor modulator (Papoutsi et al., 2005). EA has been shown to have a variety of health benefits including anti-inflammatory, anticarcinogenic, antioxidant and antimicrobial properties. Nutr Cancer. alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. 17-estradiol and ICI182780, a known estrogen antagonist, served as positive and negative controls respectively. 0021-8561 Subject: mineralization, pomegranates, humans, hormone receptors, ellagic acid, osteoblasts, estrogenic properties, cell lines, breast neoplasms In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well. Evaluation of estrogenic/antiestrogenic activity of ellagic acid via the estrogen receptor subtypes ER and ER . Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. This results in less testosterone being converted to DHT, thereby . Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins. 2010 Jun;3(6):727-37. It is revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Ellagic acid also reportedly can help the liver break down or remove cancer-causing agents from the blood. In addition, research has found that it has antibacterial and antiviral properties. Ellagic acid (EA) is a natural phenolic compound present in berries, nuts and pomegranates. Ellagic acid is an antioxidant found naturally in many of your favorite foods, including many fruits and vegetables. This makes them have a cardioprotective effect on humans. Ellagic acid estrogen "Evaluation of estrogenic/antiestrogenic activity of ellagic acid via the estrogen receptor subtypes ERalpha and ERbeta," Journal of Agricultural and Food Chemistry, vol. Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. The mushroom has many helpful compounds, of which EA is the highest. The name comes from the French term acide ellagique, from the word galle spelled backwards because it can be obtained from noix de galle , and . Ellagic acid is a polyphenol found in numerous fruits and vegetables. Second, ellagic acid stops the growth of tumors. Awards 0. Eat comfortably and take care of your health with Eden Food Farm's Pomegranate Collagen Jelly Sticks. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia . Some foods also contain a compound called ellagitannin, which your body . Third, ellagic acid causes G-arrest. Cancer Prev. A type of sugar; the chief source of energy . May 8, 2013 #1 . Aiyer, H. S. & Gupta, R. C. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. 53, no. Also known as the ox tongue mushroom, it is a parasite that resembles raw meat. 2010;3(6):727-737. 3, 727-737 (2010). Ellagic acid is a naturally occurring compound called a tannin, found in red raspberries, strawberries, pomegranates, and walnuts. They neutralize free radicals, which are key drivers of chronic . This renders the model more useful for chemopreventive interventions with translational value. (2018), PG is rich in hydrolyzable tannins precursor of ellagic and gallic acid, which play a crucial role in the physiological activity of Pomegranate. Phytoestrogens. . Ellagic acid hydrate | C14H8O9 | CID 16212384 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . It can clearly act as an anti-oxidant, and has been found, in several instances, to cause cell death (apoptosis) in cancer cells in laboratory experiments. According to the research conducted by Wang et al. of Estrogen Metabolism Harini S. Aiyer1 and Ramesh C. Gupta1,2 Abstract To determine whether dietary berries and ellagic acid prevent 17-estradiol (E 2)-induced mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen Irish rats (n = 6 per group) into five groups: sham implant + control diet, E 2 implant + control . Ellagic Acid has the ability to inhibit mutations within a cell's DNA, causing apoptosis (normal death) in cancer cells. Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. It is the dilactone of hexahydroxydiphenic acid. GreenMedInfo Summary. . Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats Harini S Aiyer, Cidambi Srinivasan, Ramesh C Gupta Nutr Cancer . Name. The effect of a chemopreventive agent, ellagic acid in reversing miRNAs modulated during E 2-mediated mammary tumorigenesis was also established. Ellagic acid has also been found to be effective in the prevention of estrogen-induced mammary tumors in rats. Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. Other berries that are rich in ellagic acid include cranberries and cloudberries. To determine whether berries and ellagic acid affect estrogen metabolism, we examined the regulation of gene expression of key enzymes involved in estrogen metabolism and signaling in the mammary tissue during the course of mammary tumorigenesis. 6. Abstract Source: Cancer Prev Res (Phila Pa). These include ellagic acid, punicic acid, phenols, and flavonoids. Ellagic acid can reduce the activity of tyrosinase and catalase, thereby inhibiting the formation of melasma. 7715-7720, 2005. Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. Ellagic acid also suppresses the expression of cyclooxygenase 2 and inducible nitric oxide synthase via the inhibition of nuclear factor-kappa B (NF-B) activity in several normal and cancer cells (8,9). View at . These materials are considered a selective estrogen Prevention of oxidative DNA damage by bioactive berry components. Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Kakadu Plum Organic 10:1 EXTRACT Powder $ 14.99 - $ 41.99 (inc GST) Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Methods . In other laboratory studies, ellagic acid seems to reduce the effect of estrogen hormone in women in promoting growth of . The present study aimed to evaluate the effects of ellagic acid on testicular tissue changes, sexual hormones, antioxidant defense system, and caspase-9 and Bcl2 gene expression in the busulfan-induced relative sterile rat model. Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. . Ellagic acid seems to have some particular anti-cancer properties. Ellagic Acid. Contains aboundant nutrients frim pomegranate (vitamin B C, ellagic acid, estrogen, polyphenol, anthocyanin, citric acid, folic acid, calcium, potassium, zinc, etc.). Ellagic acid is a naturally selective estrogen receptor- and estrogen receptor- ligand, exhibiting selective estrogen receptor modulator properties similar to those of synthetic natural . Research on ellagic acid's effect on cancer first appeared in the 1970s and . Historically, dietary chemoprevention studies have used . When mice were administered ellagitannins orally at the dose of 600 mg/kg body weight, ellagic acid was detected in urine (0.05% of the dose) as a result of absorption and metabolism of ellagitannins (Girish et al., 2009c; Seeram et al., 2004).The low concentration of free ellagic acid in plasma had . To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor . Clin Biochem 2009;42:1358-62. Download Prime PubMed App to iPhone, iPad, or Android. Ellagic acid dosage ranges from 200mg to 500mg per day.